TEMAS LIBRES
TITULO: APPLICATION OF AUTOLOGOUS PLATELET RICH PLASMA GEL IN TREATMENT OF NON-HEALING WOUNDS - BASED ON PILOT STUDY EVALUATING EXPERIMENTAL TREATMENT OF ORAL MUCOSITIS IN CHILDREN WITH ALL
Nº DE REFERENCIA 16279
TIPO PRESENTACION: Temas Libres
CATEGORIA: Cirugía Plástica
RESUMEN DE LA PRESENTACION:
ANTECEDENTES: Autologous platelet rich plasma gel is a source of many terapeutically active growth factors i.e.: EGF, FGF, PDGF, TGF (β1, β2), IGF and VEGF, which have signficant role in process of wound healing. The researches conducted on animals proved, that in the case of autologous platelet rich plamsa gel application, which contains high concentration of the growth factors, gels therapeutic and regenerating features can be used in performing many, very compicated surgeries of soft and hard tissues. These growth factors, released from dense granules and alpha-granules, in result of platelets activation are applied in regenerative medicine, and especially in treatment of non-healing wounds.
OBJETIVO: The objective of the study was to evaluate the effectiveness of autologous platelet rich plasma gel in treatment of oral mucositis caused by chemotherapy in children with acute limphoblastic leukemia.
DISEÑO: Prospective study
MATERIAL Y METODO: Between September and November 2017, in the Department of Pediatric Hematology and Oncology a pilot study was conducted. The autologous platelet rich plasma gel was used in the treatment of fungal oral mucositis (3 - 4 according to the WHO scale), which is a complication of chemotherapy. The study group consisted of 4 children aged 3 to 5 years old, treated for high-risk acute lymphoblastic leukemia according to the ALL IC protocol - BFM 2009. In addition to the autologous platelet rich plasma gel, all children received antifungal drugs (Ambisome™, Mycamine™). The control group consisted of 4 children of similar age received only antifungal drugs (Ambisome™, Mycamine™).
RESULTADOS: Healing of the fungal oral mucositis in children treated with addition of autologous platelet rich plasma gel was significantly faster, than in children treated with standard treatment method. (4 days vs. 7.5 days; p<0.05)
CONCLUSIONES: The application of autologous platelet rich plasma gel significantly shortened and improved complete healing of oral mucositis, compared to control group. Additionally, this treatment significantly bettered patient comfort. Autologous platelet rich plasma gel is new, proming treatment method, which can improve management of non-healing wounds.